I use a Canon EOS 30D. I took the out of focus Brussels Griffon with my EF 16-35mm f/2.8L II USM - most likely on manual focus.
The guy's hands are sharp. The poor puppy is soft. I only made five frames. All are soft.
I might have to start just shooting on auto-focus with my old eyes. And I was shooting with out my glasses on that day, too.
I think I need to wear the glasses, use the auto-focus and take a lot more than five frames.
Getting old is not for the faint of heart. Sigh.
(The other glass I have are the Canon EF 70-200mm f/2.8L IS USM and a Extender EF 1.4x II. My flash is the Speedlite 420EX.)